Perineural Injection Therapy (PIT)
Chronic pain has a way of draining your energy, your mood, and your quality of life. But there’s a gentle, effective therapy that’s helping patients feel like themselves again—without surgery or heavy meds.
What is PIT?
Perineural Injection Therapy (PIT) is a targeted treatment designed to calm inflamed nerves—often the root cause of chronic pain. Originally developed by Dr. John Lyftogt, PIT works by delivering a mild dextrose solution just beneath the skin in specific areas where nerves are irritated or entrapped.
It’s quick. It’s precise. And it’s changing the game for those who haven’t found relief elsewhere.
Some patients choose PIT at anu:
No steroids, drugs, or deep injections
No risk of allergic reaction (just a sugar-water solution!)
Minimal discomfort, maximum results
Ideal for nerve-related pain, including neuropathy and entrapment
Can be a breakthrough option even after other treatments haven’t worked
How Does PIT Work?
Think of it like acupuncture meets science-backed nerve support. Unlike deeper injections or surgical solutions, PIT is a surface-level treatment that uses your body’s natural glucose receptors to reduce inflammation and support healing. The result? Often immediate pain relief, with ongoing improvement as your nerves regenerate and calm down.
Common Applications of PIT
Perineural Injection Therapy can be used to treat various types of chronic pain, including:
Nerve inflammation: PIT can help reduce inflammation around nerves, allowing for improved function and pain relief.
Neuropathic pain: This type of pain, often caused by nerve damage, can be effectively managed with PIT.
Nerve entrapment: Conditions such as carpal tunnel syndrome, where nerves become compressed or trapped, can benefit from the hydrodissection technique used in PIT.
Neuralgia: PIT can help alleviate pain caused by irritated or damaged nerves.
Connective tissue disorders: By targeting the connective tissue surrounding nerves, PIT can help alleviate pain and inflammation associated with conditions such as fibromyalgia and myofascial pain syndrome.
Misconceptions About Perineural Injection Therapy (PIT)
Trying something new for chronic pain can raise questions—and that’s totally normal. Let’s clear the air with the facts behind some common misconceptions about PIT.
Myth 1: PIT is just like other injection therapies.
Fact: Nope. PIT zeroes in on nerve inflammation using a gentle dextrose solution to release tight connective tissue and calm the nerves. Unlike prolotherapy or neural therapy—which dive deeper into joints and target tendons or ligaments—PIT is all about treating swollen, irritated nerves at the surface.
Myth 2: PIT only gives temporary relief.
Fact: Many folks find their pain sticks around for the long haul after PIT. That’s because PIT treats the root problem—nerve inflammation—and helps nerves heal and regenerate over time.
Myth 3: PIT is painful and invasive.
Fact: Think small, surface-level injections with minimal discomfort. Most patients say it’s quick and easy, with any soreness fading fast.
Myth 4: PIT isn’t backed by science.
Fact: Science says otherwise. Studies show PIT can significantly reduce pain and improve function, making it a smart option for many dealing with chronic nerve pain.
Myth 5: PIT only works for a narrow range of pain types.
Fact: PIT is versatile. Whether it’s nerve inflammation, neuropathic pain, nerve entrapment, or neuralgia, PIT can be tailored to fit your unique pain story.
Backed by Science. Built for Relief.
Perineural Injection Therapy (PIT) isn’t just promising—it’s proven.
In a study on patients recovering from total knee replacement, PIT delivered significant pain relief and functional improvements when added to standard recovery protocols. In fact, over 93% of patients reported excellent or good outcomes—higher than those who followed surgery protocols alone.
Another clinical trial focused on patients with knee pain from chondromalacia patella. The results? When paired with at-home physical therapy, PIT helped reduce pain and stiffness and improved mobility more effectively than physical therapy alone.
Simple. Low-risk. Backed by science. And a powerful option for anyone looking for long-term relief without the side effects.
