Research says that a low level of the 2-hydroxyestrone and a high level
of 16 alpha-hydroxyestrone is associated with an enhanced risk of breast
cancer. DIM increases 2-hydroxyestrone and therefore improves the 2/16
hydroxyestrone ratio making it very protective for women and men at high risk
for this condition. Research by Bradlow has shown that DIM also reduces
availability of 4-androstenedione for aromatization to estrone a more
dangerous form of estrogen. He concludes that DIM is more potent than I3C at
protecting against breast cancer due to decreased formation of 16 alpha-
hydroxyestrone from estrone.
DIM supplementation improves the estrogen ratio in a favorable direction that
protects both men and women without the negative effect of raising 4
hydroxyestrogen as seen with I3C. DIM does not block ovulation the way I3C
does and can be used safely along with Tamoxifen unlike I3C.
DIM should be considered first line therapy for hormone imbalances that can
lead to negative conditions such as PMS PCOS endometriosis fibroid tumors
menopausal symptoms weight problems and the list goes on.
Recent research is positive so far that DIM improves weight loss resistance
due to hormonal imbalance.